DETECTION OF LOW MOLECULAR WEIGHT MAST CELL ACTIVATING FACTORS IN SERA FROM PATIENTS WITH CHRONIC SPONTANEOUS URTICARIA Short Title: Low m.w. mast cell activating factors in CSU
نویسندگان
چکیده
Medicina Interna, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy, SC Medicina Interna a Indirizzo Pneumologico, AO Fatebenefratelli e Oftalmico, Milano, Italia. Dipartmento di Scienze e Tecnologie Biomediche, Università di Udine, Udine, Italy Dipartmento di Scienze Mediche, Chirurgiche e della Salute, Università di Trieste, Ospedale Universitario di Cattinara, Trieste, Italy Unità Operativa di Dermatologia, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milano, Italy Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.
منابع مشابه
Detection of Low-Molecular-Weight Mast Cell-Activating Factors in Serum From Patients With Chronic Spontaneous Urticaria.
BACKGROUND AND OBJECTIVES Functionally active autoantibodies to IgE and to the high-affinity IgE receptor (FcεRI) can be detected in serum in about 40% of patients with chronic spontaneous urticaria (CSU). Recent studies showed that serum from patients with CSU can induce activation of mast cells, irrespective of whether they carry high-affinity IgE receptors. To evaluate mast cell activation i...
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BACKGROUND Chronic spontaneous urticaria (csU), which is characterized by recurrent episodes of mast cell-driven wheal and flare-type skin reactions, is often associated with elevated total IgE levels and thyroid autoimmunity. We speculate that some csU patients express IgE autoantibodies against thyroid antigens such as thyroid peroxidase (TPO), which could bind to skin mast cells and induce t...
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BACKGROUND In chronic spontaneous urticaria (CSU) mast cell activation together with inflammatory changes in the skin are well documented and may play an important role in mechanisms of tissue oedema. OBJECTIVES To confirm and extend these observations by measuring microvascular markers, leucocytes and mast cell numbers in lesional and uninvolved skin and to compare findings with a control gr...
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Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. H...
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